Sajid Javid and Rishi Sunak, two senior members of the UK Cabinet, resigned on Tuesday, APA reports citing The National News.
Sajid Javid resigned as health secretary from Mr Johnson's government.
"I have spoken to the Prime Minister to tender my resignation as Secretary of State for Health & Social Care," Mr Javid wrote on Twitter.
"It has been an enormous privilege to serve in this role, but I regret that I can no longer continue in good conscience," Mr Javid said.
Rishi Sunak said he was resigning as chancellor, writing on Twitter: “I recognise this may be my last ministerial job, but I believe these standards are worth fighting for and that is why I am resigning.”