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‘Doomsday’ Covid variant detected in South Africa even worse than Delta strain

31 August 2021 07:53 (UTC +04:00)

A “doomsday” Covid variant has been detected in South Africa – and there are warnings it is worse than the Delta variant.

A new preprint study by South Africa’s National Institute for Communicable Diseases warns the new variant has “mutated substantially” and is more mutations away from the original virus detected in Wuhan than any other variant previously detected.

The new variant, known as C. 1.2, first emerged in South Africa but has also been detected in England, China, the Democratic Republic of the Congo, Mauritius, New Zealand, Portugal and Switzerland.

It could pose challenges to the first generation of vaccines. Scientists say it’s also possible that people in the United Kingdom who were infected with the earlier variants could be vulnerable to reinfection.

Epidemiologist Dr Eric Feigl-Ding said the research suggested the new variant has “mutated substantially” and is more mutations away from the original virus than any other variant detected so far worldwide”.

“What does that mean? It means that C12 variant has somehow mutated so fast and far that it is now the furthest mutated variant found to date. It has mutated the greatest genetic distance from the original Wuhan 1.0 strain – and implies potential troubles for 1.0 vaccines,’’ he said.

“It gets worse with C12. It has a 1.7x to 1.8x faster mutation rate than the average of all other variants. The authors note this coincides with the emergence pattern of other really bad VOC variants.

“Consider this a hurricane warning on the next potential variant.”

While the new study is yet to be peer-reviewed, experts say the discovery underlines the risks of abandoning the basics of infection control.

That means things like washing your hands, social distancing and possibly even the use of masks among the vaccinated will continue to be a frontline defence for some time to come.

Genetic variants of SARS-CoV-2 are not new. They have been emerging and circulating around the world throughout the Covid-19 pandemic.

Variants of concern are classified as those where there is evidence of an increase in transmissibility, more severe disease, increased hospitalisations or deaths and reduced effectiveness of treatments or vaccines.

The Delta variant, which is currently causing chaos in NSW, Victoria and across the globe, is classified as a variant of concern.

The original Alpha strain of Covid that emerged in the United Kingdom and was previously regarded as the most transmissible before Delta arrived is another.

However, there is a category of variant that is regarded as even more severe. Scientists call this a “high consequence variant”.

So far, a high consequence variant has not emerged during the pandemic. If it does, it would be a variant with a demonstrated ability to outfox vaccines, more severe clinical disease and increased hospitalisations.

Currently, experts say there are no SARS-CoV-2 variants that rise to the level of high consequence.

“There are currently four Variants Of Concern (Alpha, Beta, Gamma and Delta) and four Variants of Interest (Eta, Iota, Kappa and Lambda) in circulation globally,’’ the South African research paper states.

“Of these, Alpha, Beta and Delta have had the most impact globally in terms of transmission and immune evasion, with Delta rapidly displacing other variants to predominate globally, including in South Africa.

“Ongoing genomic surveillance in South Africa also detected an increase in sequences assigned to C. 1 during the third wave of SARS-CoV-2 infections in May 2021, which was unexpected since C. 1, first identified in South Africa was last detected in January 2021. Upon comparison of the mutational profiles between these and older C. 1 sequences (which only contain the D614G mutation within the spike), it was clear that these new sequences had mutated substantially.”

The study also found that the C. 1.2 lineage has a mutation rate of about 41.8 mutations per year, which is nearly twice as fast as the current global mutation rate of the other variants.